Making Sense of Medicine http://www.amygivler.com Thoughts on health by Amy Givler, MD posterous.com Tue, 21 Feb 2012 06:25:00 -0800 When Does the Brain Start to Slip? http://www.amygivler.com/when-does-the-brain-start-to-slip http://www.amygivler.com/when-does-the-brain-start-to-slip

Screen_shot_2012-02-20_at_5
What I’m going to share may not be good news – unless you are relieved to know why you keep forgetting where you parked the car. You know that mental slowness that comes with old age? Well, the villain may not be old age. The decline seems to begin in the 40s.

A study just published in British Medical Journal (BMJ) looked at data from evaluations of 7400 British civil servants over a decade of follow-up. The people in the group who were 45-49 when the study began declined in mental sharpness 3.6 percent over the next ten years.

With each group of older people (ages 50-54, 55-59, 60-64, 65-70 at baseline) there was a progressively larger decline, though women in the oldest age group declined less than men – only 7.4 percent over the decade, versus 9.6 percent in men.

So what did the researches study to show this mental decline? These are the kind of nitty-gritty details in medical studies that fascinate me, so I am passing them on to you. They tested five areas of brain power:

·      Memory – They spoke 20 words over 40 seconds, then asked the participants to write down as many of them as they could remember.

·      Reasoning – They used a standard test to measure this, looking for the ability to identify patterns and infer principles.

·      Phonemic fluency – “In one minute, write as many words that begin with “S” as you can think of.”

·      Semantic fluency – “In one minute, write as many names of animals as you can think of.”

·      Vocabulary – They used a standard 33-word multiple-choice test.

Interestingly, vocabulary didn’t decline with age. We retain our ability to know what words mean.

I know I don’t usually litter my posts with dull statistics, but I felt like the exact percentage of mental decline would be interesting. If you want to slog through the research study yourself, the link is http://www.bmj.com/content/344/bmj.d7622.full?linkType=FULL&resid=344/jan04_4/d7622&journalCode=bmj . All BMJ articles are free for anyone to read.

So what can we do about this? Actually, there’s a lot we can do to slow down the brain’s aging. Staying a healthy weight helps a lot. Obesity has been shown to increase rates of dementia. So has high blood pressure, and high cholesterol levels. Getting regular exercise is key.

So does that inspire you (as it does me) to dust off your New Year’s resolutions and return to your weight-loss plan and to get moving with some exercise? Yes, yes! Let’s keep our brains sharp.

 

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Mon, 06 Feb 2012 11:14:00 -0800 The Lingering Effects of Katrina http://www.amygivler.com/the-lingering-effects-of-katrina http://www.amygivler.com/the-lingering-effects-of-katrina

Screen_shot_2012-01-26_at_12
I spoke recently with a friend who has moved to a town near New Orleans. Much of it flooded during Hurricane Katrina’s aftermath. The entire town was evacuated, and most families lost everything they owned. My friend, a nurse practitioner, says every patient works Katrina into every conversation.

“Before Katrina I lived in such-a-such a place…”  Or, “This problem started a year after Katrina.” The hurricane changed their lives – radically – and so everything links to it, like spokes radiating out from the hub of a wheel.

Living in North Louisiana, I was shielded from much of Katrina’s impact. Our community opened shelters, of course, and afterwards many evacuees settled here. But for those who lost everything, this was no small blip in the path through life.

My nurse practitioner friend’s patients are mostly middle class. If they had a rough time, think how difficult it was for the poor to go through the losses of Katrina. A new study published in the journal Social Science and Medicine was able to analyze exactly that. (http://www.princeton.edu/main/news/archive/S32/74/14C15/index.xml?section=topstories )

Remarkably, the authors of the study had surveyed 532 low-income mothers, average age 26, two years before Hurricane Katrina. They had asked questions about their mental and physical health as well as their family situation. Then when Katrina hit, the researchers realized they had a perfect “before” snapshot of a group of people who just experienced a traumatic event. So they “hunted” the women until they found most of them, now scattered across the country, asking them to complete several more surveys over the next five years.

The surveys assessed the level psychological distress the women had, as well as how many post-traumatic stress symptoms (PTSS) they were experiencing. To evaluate PTSS, they asked how often they thought about the hurricane in the past week, and whether they had thoughts on Katrina they couldn’t suppress. Even five years later, 33 percent of the women still had PTSS, and 30 percent of them had high levels of psychological distress. The more stressors they had gone through during the storm (home damage, death of a friend or relative, being in danger or lacking food, water, or medical care), the more likely they were to have persistent PTSS or psychological distress.

These levels of mental stress are higher than found in previous studies of people who have survived disasters. Of course, Katrina was more disruptive than most natural disasters. This study shows that people who have gone through something tough may need more emotional support – and for a longer time – than seems obvious. The poor, who have fewer resources to fall back on, may need even more.

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Wed, 01 Feb 2012 10:13:00 -0800 Mothering Young Adults http://www.amygivler.com/mothering-young-adults http://www.amygivler.com/mothering-young-adults

Screen_shot_2012-02-01_at_5
This past weekend I saw the movie Warhorse, which I recommend, by the way, and one side plot has stuck with me. The central story is what happens to a horse which has been conscripted for use in WWI. Two of the many people who interact with the horse are two young German brothers. Very young brothers. In fact, one is only 14. 

It sounded like the boys’ mother knew the younger one was enlisting, but made the older brother promise to keep him safe. The older brother took that promise very seriously, and was willing to disobey his commanding officer to keep it.

When the younger brother is sent to the front lines, the older one is forced to stay back with the horses. He watched his brother march off, deeply conflicted. The next thing we see is him galloping up to the line of marching men, leading a second horse, and grabbing his brother from the line. They gallop off. The hide out in a barn, where they are found by their commanding officer, and then summarily shot.

It was very hard to see them killed, since I had gotten to know and like them. But I didn’t realize how deep an impression that scene had made on me until the next morning, when I woke up in a cold sweat. As soon as I was conscious I realized I had been dreaming about those two boys.

The older brother was foolish to go AWOL, but I think the mother was more foolish, still. What do I want for my children, as a mother? Many things, but notably for them to stay alive. She insisted on a promise from the older son, and he was willing to risk his life to keep that promise. If the younger son had died, the mother would have been devastated, and the older son didn’t want to live with that. So instead of having one son safe, she lost them both.

Yes, this post is a little different than my usual fare. But in a sense it is about health – keeping young men alive (that’s healthy!) and protecting the hearts of mothers from crushing sorrow.

What choke-holds do I place on my children? I’ve been thinking about that this week. I want them to live for God, within their own moral framework, and not to try to live up to my expectations. Making me happy can’t be their goal. For if I cling to them, I just might lose them entirely.

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Mon, 23 Jan 2012 12:45:00 -0800 Who Gets Abortions? http://www.amygivler.com/who-gets-abortions http://www.amygivler.com/who-gets-abortions

Screen_shot_2012-01-23_at_2
Today is the 39th anniversary of the U.S. Supreme Court decision that legalized abortion, commonly known as Roe v. Wade. I knew I wanted to write about abortion today, and so have been doing some research. The research has gripped me. You see, I consider abortion as the taking of a human life, and so learning how many of those human lives are interrupted each year has been sobering.

According to the Guttmacher Institute (http://web.archive.org/web/20080313054435/http://www.guttmacher.org/in-the-know/incidence.html ) 46 million abortions occur yearly, worldwide. I can’t wrap my mind around 46 million, so I’ll focus on the U.S., in which 3400 occur every day.

And who are those 3400 women? 41 percent are white, 32 percent are black, and 20 percent are Hispanic. Woman for woman, though, more blacks and Hispanics have abortions, compared with white women. For every 1000 white American women, 13 have an abortion each year, whereas black women have 49 per 1000, and Hispanics have 33 per 1000. The Guttmacher Institute (http://web.archive.org/web/20080311171704/http://www.guttmacher.org/in-the-know/characteristics.html) concludes, “Over time, women having abortions have become increasingly likely to be poor, nonwhite and unmarried, and to already have one or more children.”

If you take a group of 45-year-old American women, who have reached the age when the likelihood of pregnancy is small, one out of three will have had an abortion. A lot of those women regret that abortion, and I ache for them. 

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Fri, 20 Jan 2012 05:14:00 -0800 The Risk of Death in Grief http://www.amygivler.com/the-risk-of-death-in-grief http://www.amygivler.com/the-risk-of-death-in-grief

Screen_shot_2012-01-20_at_7
Lest you had any doubt that the brain is connected to the heart, here comes a study that links those two oh-so-important organs. People who were in the hospital because of a heart attack (also known as a “myocardial infarction”, or “MI”) were asked, among other things, whether a loved one had recently died. Of the 2000 people asked, 270 reported that someone they loved had died within the past six months, and 19 people had lost a loved one within the past day.

To put it another way, the first day of grief increased the risk of MI by more than twenty times what would be expected on a day without such sorrow.

Over the years I’ve heard of multiple loving couples who have died within a week of each other. I’ve heard people say: “He (or she) died of a broken heart.” The above study, published in the medical journal Circulation, supports those comments.

What I take away from this research is a renewed resolve to do what I can to support people who are grieving. Grief is a painful time. The way “life was supposed to be” has been altered, perhaps abruptly. I was walking purposefully down one path, thinking I could see my goal in the future, and now, suddenly, I am forced to walk down this other path, with no goal visible. The process of adjusting to this new reality is what we call grief. And it’s no fun.

Maybe all a grieving person needs is a wordless hug. I suspect that’s all that person needs. 

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Mon, 02 Jan 2012 08:31:00 -0800 Moisturizing Skin http://www.amygivler.com/moisturizing-skin http://www.amygivler.com/moisturizing-skin

Screen_shot_2012-01-02_at_11
When I was in medical school on my dermatology rotation, we joked that all skin treatments boil down to three decrees: If it’s wet, dry it. If it’s dry, wet it. And if in doubt, use steroids.

Some other time I’ll discuss the “drying” of skin, or the use of steroids (which are not, by the way, the kind of steroids taken illegally by athletes!) Today I’ll cover how to keep the skin “wet” – and some principles of moisturizing.

Skin is our first line of defense against disease. Bacteria, viruses, parasites – dangers lurk everywhere. But our epidermis (the outer layer of our skin) blocks them almost always. When people have inflamed skin, the epidermis becomes disrupted and infectious particles can enter their body. 

The key to keeping the epidermis intact is keeping it moist. Now, I’m talking about moisture just below the surface of the skin (within the epidermis), so the outside surface doesn’t feel wet. There are molecules within the epidermis that hold onto water, and which draw water to the area – from both directions. That is, from deeper inside the body and from the outer surface of the skin. 

Dry skin is itchy skin. There are skin diseases which lead to excessive water loss from the epidermis, the most common being eczema, or “atopic dermatitis”. Even those of us without eczema, however, can benefit by keeping our epidermis as moist as possible.

There are three basic types of moisturizers: lotions, creams, and ointments. A lotion is water based, which means that after you rub it in, the water in the lotion will evaporate. This makes lotions not the best option for dry skin, for you may end up having less moisture in the epidermis than you did before.

A cream has a small amount of water and more oils than a lotion, in addition to various chemicals which help to keep it from feeling greasy. An ointment has no water at all, which makes it a barrier keeping water from evaporating.

The most effective way to keep water in the epidermis is to apply either a cream or an ointment right after a bath or shower. During the shower, it’s best not to scrub the skin, but just gently wash with soap or another cleanser. Then, immediately after toweling off, apply a cream or ointment. The water from the shower is trapped on the skin, and is slowly absorbed into the epidermis.

Oily skin benefits from moisturizers, also, but it’s best to use one that doesn’t fill the pores, which might lead to an acne flare. Look for “non-comedogenic” on the label.

Three creams which many dermatologists recommend are Eucerin, Cetaphil and Nutraderm. For ointments, the cheapest way to go is plain old petroleum jelly (brand name Vaseline). Dermatologists also often recommend the ointment Aquaphor.

As people get older, their skin tends to be less oily because the glands that produce oil become less active. That means that more water evaporates from the surface of the skin, and less is trapped within the epidermis. So often older people find themselves needing a moisturizer, generally an ointment, for the first time. 

 

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Sat, 17 Dec 2011 08:36:00 -0800 Jet Lag Tips http://www.amygivler.com/jet-lag-tips http://www.amygivler.com/jet-lag-tips

Screen_shot_2011-12-17_at_10
Continuing the theme of sleep, and when achieving it is difficult, let’s move on to jet lag. Jet lag is a combination of symptoms: sluggishness, gut problems (generally constipation), and an overall unpleasant feeling. At the root is a problem with sleep. We can’t get to sleep when it’s time for bed, and we can’t awaken when it’s time to get up. Jet lag happens when we cross several time zones rapidly, and our “internal clock” becomes confused.

Crossing the ocean on a ship gives the body time to the slightly earlier sunrise every day (traveling east) or the slightly later sunrise (traveling west). Airplane travel across several time zones is too speedy for most of us to adjust.

Our bodies can “expand” the day more easily than it can “compress” it. Thus traveling westward, and ending up with more hours of daylight, is easier to adjust to than traveling eastward, and ending up with a shorter day.

Most people who cross more than four time zones will experience jet lag. The pineal body, a gland in the skull but just outside the brain proper, produces the hormone melatonin, which helps to regulate our “sleep/wake cycle”. When the sun sets, the gland pours out melatonin. But the gland has some sort of an internal mechanism as well as just sensing when it is dark. If we compress our day (by traveling east), it takes several days for it to “catch up” and produce the right amount of melatonin by bedtime in the new place.

For every time zone crossed traveling east, it takes one approximately one day to fully adjust. Traveling west takes less time, by about a third.

There are ways to speed up the process of adjusting, and lessening jet lag. Going west, a traveler should try to stay awake until the regular bedtime at the new destination. Going east, a traveler should be outdoors in the afternoon and early evening, so the body clock senses the dimming light.

For both east and west travel, it’s best to eat meals at your normal mealtime, according to the clock at your current destination. Also, it’s best to get plenty of exercise – take a long walk and take in the new sights.

Taking melatonin can be helpful. A Cochrane review article in 2002 looked at ten placebo-controlled papers, studying almost a thousand people who took melatonin for jet lag. The bottom line is that taking it significantly helped many of the people. The dose ranged from 0.5mg (which is not commercially available unless you buy the liquid to take that low of a dose) to 5mg. In the U.S. most drugstores carry 3mg melatonin pills without a prescription. Interestingly, the 0.5mg was almost as effective as the 5mg, although the higher dose led to slightly less time before the onset of sleep, and the quality of sleep was also slightly better.

The authors of that review suggested taking melatonin at bedtime for the first four nights at the new destination. For eastward travel (from the U.S. to Europe, say) they also recommend taking a dose on the day of travel, as you are traveling. For that dose, figure out what your regular bedtime will be at the new location and take a dose at that time.

I know it’s hard to remember east versus west, so here’s a memory aid:

If you are in California and your mother is in Rhode Island, she is eating supper while you eat lunch. If you instantly transport yourself to her side, less of your day will be left than if you were still in California. You are asking your body to compress its time clock into a shorter day. That is hard for your body to do. Stretching your day out, going west, is easier on your body.

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Sat, 10 Dec 2011 11:01:00 -0800 Melatonin: Is It Safe? Is It Effective? http://www.amygivler.com/melatonin-is-it-safe-is-it-effective http://www.amygivler.com/melatonin-is-it-safe-is-it-effective

Screen_shot_2011-12-10_at_1
Many of my patients, over the years, have taken melatonin. Many other patients have asked me about it, but I’ve never had much to say. I hadn’t heard anything particularly bad about it, but couldn’t really recommend it. “Research melatonin” has been on my “To Do” list for a long time.

So here’s what I’ve discovered: Melatonin is a hormone. I’ve known that since medical school, of course, but that fact has struck me as peculiar these past few weeks. Why? Because it’s sold over the counter, and many people take massive amounts of it. No other hormone is available like this. The use of other hormones, such as insulin and thyroid hormone, need careful monitoring. Is melatonin so universally safe that it can be taken at any dose, for however long? The more we learn about melatonin, the less that seems to be the case.

Hormones are substances produced in one place that then go into the bloodstream and have their effect somewhere else. Melatonin is produced in the pineal body, which is just outside the brain proper. Ten times as much of it is made during the night as during the day. Our bodies sense when it is dark and tell the pineal body to make melatonin. If we cross six time zones, however, it takes a few days for the pineal to catch up and produce melatonin at the proper time. Hence comes Jet Lag.

So do people with insomnia benefit from melatonin? Many of them swear by it, but I’m wondering whether they are taking too much. The pills in pharmacies are generally 3mg or 5mg. But the amount that reproduces what our bodies produce at night is equivalent to somewhere between 0.1mg and 0.5mg. Higher doses flood the brain with melatonin, and make it actually less sensitive to its effects. So here is where it is not good to follow the “If a little is good, then more is better” principle. Since a little is all that is needed, stick with a little.

Studies are showing that the ideal amount of melatonin for sleep problems seems to be 0.3mg. But how can you take “0.3mg” when the pill is 3mg? Do you crumble it up and take a tenth, somehow? Not practical. There are liquid preparations available, with one dropperful giving 1.0mg. So you could take a third of a dropperful. If you can’t find it at your pharmacy, check online at www.drugstore.com.

As we age, we gradually produce less melatonin. I wonder if this is why so many older people have trouble sleeping. In the last few weeks, since I’ve been reading about melatonin, I’ve started recommending it to my older patients with insomnia. But I urge them to use the liquid so they only take 0.3mg a night. They may end up needing a little more, but, as with all medications, I much prefer starting at a low dose and creeping up slowly. I’ll follow up in a few months with how people have responded. 

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Wed, 30 Nov 2011 07:43:00 -0800 Sleep Hygiene, Or, "How To Sleep" http://www.amygivler.com/sleep-hygiene-or-how-to-sleep http://www.amygivler.com/sleep-hygiene-or-how-to-sleep

Screen_shot_2011-11-30_at_9
Hygiene is a funny word. It makes me think of washing my hands. But the word has a broader definition than cleanliness, and that is “preservation of health”.

Sleep is an important part of health. No one knows exactly why it is so important, but everyone knows they need it, and how miserable they are when they don’t get enough of it. So here are a few tips on how to make sure you’re optimizing your chance for restful sleep.

One, go to bed at the same time, and get out of bed at the same time – even on weekends. Most adults need between seven and eight hours of sleep.

Two, try to not go to bed when you are all keyed up. That means not smoking (nicotine is a stimulant) and not drinking anything with caffeine for several hours before bed. (While you’re at it, just stop smoking forever.)

Three, exercise – but not within four hours of bedtime. Regular aerobic exercise definitely helps people sleep better, but not if done right before bed.

Four, keep the bed as dark and quiet as possible. Even if we may doze off with the television going, or the light on, our brains still perceive these things as stimulation. Even a low level of light (think of the digital clock face staring at you, or the little light on your plugged-in electronic device) may be keeping you from sleeping at the deeper, more restful, levels.

Five, don’t solve the world’s problems in bed. Or yours, either. For one thing, problems loom bigger at night. If I awake and find myself worrying and my mind racing, I try to separate myself from the anxiety by talking to myself. “Yes, this is a tangled situation, Amy, but this is not the time to tackle it.” I also talk to God (also known as prayer), which is basically putting the problem into the hands of someone bigger than me.

Another little tip I use is to reflect upon whether I am comfortable when I first get into bed. I may be able to ignore the fact that my feet are cold when I have been walking around, but once I’m in bed, and my brain and body slow down, a small annoyance becomes a big one. Also, it becomes a huge effort to get up out of bed and put on socks when I am drowsy. Better to do it when I haven’t been in bed for very long.

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Mon, 28 Nov 2011 10:51:00 -0800 Tryptophan and Sleepiness http://www.amygivler.com/tryptophan-and-sleepiness http://www.amygivler.com/tryptophan-and-sleepiness

Screen_shot_2011-11-26_at_12
On Thanksgiving day, I noticed three different newspaper comics mentioned “tryptophan” as part of their humor. In each, eating too much turkey had led to sleepiness, because turkey contains lots of tryptophan. Clearly tryptophan’s association with sleep has entered the public consciousness.

But in case you’re tempted to pick up a bottle of tryptophan pills as a sleep aid, I want to interject a few words of caution.

First – what exactly is tryptophan? It is an amino acid, one of the building blocks of proteins. It is an “essential” amino acid, which means that our bodies don’t make it and we have to obtain it from food. Our bodies use tryptophan to make the hormone serotonin, low levels of which are associated with depression. Serotonin, in turn, is used by our bodies to make the hormone melatonin, which is associated with sleep.

In the 1980s thousands of people became ill with a previously-rare illness called Eosinophilia-Myalgia Syndrome (EMS), which caused muscle and nerve pain and skin thickening. The culprit was suspected to be (never proved) L-tryptophan supplements, which were very popular at the time. One of the two main Japanese manufacturers had apparently recently changed their synthesis process, and it had an impurity that was blamed. All tryptophan was taken off the market, and it’s never since been as popular.

Tryptophan has been back on the market for 15 years, and the current main Japanese supplier attests that it is pure. However, there have been scattered cases through the years, including a woman taking 1500mg of it nightly, as reported in Arthritis and Rheumatism (http://www.ncbi.nlm.nih.gov/pubmed/21702023).

The researchers didn’t find any impurity in the brand of L-tryptophan she was taking. Her genetic makeup, however, made her susceptible to developing EMS.

Now let’s get back to talking turkey. For a 3 ½ ounce serving of turkey (100 grams), you consume 330mg of tryptophan. If you ate the same amount of caribou, you would get 460mg (I just had to add that for my Canadian readers). Fish, pork, chicken, soybeans (think tofu), cheese, nuts, and sesame and sunflower seeds give you a lot, also.

So is the turkey the reason we all needed to take a nap on Thanksgiving? Probably not. Tryptophan needs to be taken on an empty stomach (without other amino acids to compete with it) to have a significant effect. Much more likely our snoozing was caused by the quantity of food we ate. It takes energy to digest a huge meal, so our bodies divert the blood supply to our stomachs, and our brain tries to discourage us from much other activity, making us sleepy.

So go ahead and prepare yourself a leftover turkey sandwich. Just make it – for your stomach’s sake – a small one. 

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Sat, 19 Nov 2011 20:27:00 -0800 Taking Supplements May Harm, Not Help http://www.amygivler.com/taking-supplements-may-harm-not-help http://www.amygivler.com/taking-supplements-may-harm-not-help

Screen_shot_2011-11-19_at_5
An article that came out in October bothers me. It was published in Archives of Internal Medicine and made the connection between taking certain vitamins and minerals and a higher risk of dying.

What’s going on here? Aren’t taking supplements supposed to make us live longer? Why are we spending our hard-earned money on something that is not only not helping, but looks like it’s hurting?

This study looked at information from the Iowa Women’s Health Study, a big database of information on 40,000 women who have been enrolled since 1986, when they were at least 55. They have asked these older women what supplements they have taken over the years, in addition to many other questions. All other things being equal, women who took vitamin B6, folic acid, iron, magnesium, zinc, a multivitamin, or copper were slightly more likely to die, over the years, than women who didn’t.

Now the increased risk of dying was small, ranging from 3 to 6 percent, except for copper supplements, which, over the 18 year follow-up, was associated with a whopping 18 percent increased risk of dying.

On the bright side, the women taking calcium over the years had a 4 percent lower risk of dying.

Still, I think the chances that news like this will discourage few people from taking supplements. After all, at the beginning of the study, in 1986, 63 percent of the women were taking at least one supplement. By the end of the study, in 2004, 85 percent of the women were. Supplement use is firmly embedded in our culture.

I have to add that I urge many of my patients to take supplements. If I think they are under-nourished, I ask them to take a multivitamin. Women, especially, need a large amount of calcium, which it is very hard to get in the diet, unless they take supplements. People who are anemic may need to take iron.

I’m not a big fan of government regulation, but I respect the emphasis on safety the Food and Drug Administration (FDA) puts on medicines. The trouble is, supplements are considered, in the eyes of the FDA, to be “foods” and not medicine. So, basically, medicines have to show themselves to be helpful in order to come on the market. Supplements, however, can come on the market at any time, by anybody, and to take them off the market they have to be shown to be harmful.

My point is -- the supplements that many Americans are taking could  possibly have less of the substance than the label states, or other things could be in there that may be harmful. There is a company that tests supplements independently, and their results can be found at www.ConsumerLab.com. For around $30 a year, anyone can have access to their extensive tests on specific brand name supplements. If you take supplements (which can be expensive!), joining ConsumerLab might be a good investment, because you can make sure you’re getting the promised ingredients – and nothing else.

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Wed, 16 Nov 2011 07:56:00 -0800 Ever Heard of a Neti Pot? http://www.amygivler.com/ever-heard-of-a-neti-pot http://www.amygivler.com/ever-heard-of-a-neti-pot

Screen_shot_2011-11-16_at_10
A friend asked me to research the Neti pot, and so I read about it and decided to write about the whole concept of swishing salt water into your nose. Is this beneficial? Who should do it? 

But just as I was gathering my thoughts, a newsletter from Louisiana’s Office of Public Health arrived. It told the story of a man from southern Louisiana who died from a brain infection of an amoeba (a rare cause of brain infection). When a bizarre death like this happens, the public health detectives get to work. Only three or four people die in America from this each year, but they generally are people who swim in freshwater, where the amoeba lives. But this guy didn’t. He did, however, use a nasal rinse container, and evidence of the amoeba was found in the family’s water heater, which wasn’t set at a high enough temperature. Infectious disease specialists recommend 160°F (71°C). 

But wait! I’m not telling this story to convince you that nasal rinsing is perilous (nor to gross you out). I think nasal rinsing can be done safely. It’s all a matter of keeping everything clean.

So first, why do nasal rinsing at all? More and more Ear, Nose and Throat (ENT) doctors are recommending it. Three main benefits are:

·      Saltwater washes mucus from the nose, as well as pollen and other things you might be allergic to.

·      Irrigation keeps the nose tissues moist.

·      The tiny hairs that move mucus, called “cilia”, are better able to do their work if they are washed in this way.

I know several people who are sure that regularly irrigating their nose has meant fewer sinus infections.

So how do you do it – and safely? First, if you choose to use a Neti pot, which can bought at most pharmacies, be sure that it can survive in dishwasher, or similarly hot and soapy water. Neti pots are also available in ceramic in various shapes – looking something like a cross between Aladdin’s lamp and a cute little teapot. The key is keeping it clean, and the dishwasher is the best way to do that.

I found a range of “recipes” for the saltwater solution, but here is one that seems reasonable:

·      Use tap water that has been boiled and then cooled.

·      Fill a quart-sized glass jar that is freshly out of the dishwasher.

·      Add a heaping teaspoon of pickling/canning salt. (Apparently this form of salt doesn’t have all the additives that table salt has.)

·      Add a teaspoon of baking soda (pure bicarbonate). Saltwater alone might irritate the tissues, so baking soda helps with that.

·      Swirl to mix.

·      Keep covered, and throw away after a week.

To use the Neti pot, you fill it with the solution and then tilt your head over the sink (or do it in the shower!) so that one nostril is higher than the other. You pour the solution slowly into the top nostril and it runs out the bottom one. Then you repeat on the other side. One Neti pot should be enough for both sides.

Let me know if you have “tips” (or cautions) to add. Remember – be sure everything is clean, clean, clean!

 

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Fri, 11 Nov 2011 15:34:00 -0800 Do Babies Get Too Many Shots? http://www.amygivler.com/do-babies-get-too-many-shots http://www.amygivler.com/do-babies-get-too-many-shots

Screen_shot_2011-11-11_at_5
First, I hope everyone has been able to write “11/11/11” at some time today. If not, pull out your diary and write a few lines – after you have written the date, of course.

My last post stirred a lively discussion on my Facebook page about the value of  vaccines, and whether we are asking too much of our children’s immune systems. In 1980, children under two only received vaccines to prevent seven diseases, but today they are protected from ten diseases, and six of those involve shots on more than one occasion.

Ouch.

First – how vaccines usually work: Tiny bits of protein or polysaccharide antigens are given which aren’t the entire virus or bacteria so they can’t cause infection. People then produce an immune response that they then tuck away in their “immune memory” so if they’re exposed in the future they can fight the disease right away.

I also want you to know that I was way, way, way more obnoxious about the need for vaccines until the day I sat waiting for the nurse to enter the exam room to give my cooing, two-month-old firstborn her first shot. I looked at her creamy, perfect skin, which would soon be pierced, and I felt my heart ripping. Never again would I flippantly insist on the need for immunizations. I argue for them, sure, but I understand any lack of enthusiasm I encounter. 

So have we gone overboard and do we give too many? It turns out we are giving far less, yes less, than we used to. Remember those vaccines for seven diseases in 1980? Those vaccines contained, collectively, more than 3000 little “antigens” that the babies then responded to. The vaccines kids currently receive contain less than 200 antigens – in total.

Also, studies have been done which show that infants can produce immune responses to multiple vaccines given simultaneously, and are just as protected as if they had received them one at a time. Moreover, babies who are fighting a mild illness (and so their immune system has been activated) still produce an excellent response to immunization.

It seems we are underestimating a baby’s immune system. It’s more vigorous than we give it credit for. 

Now, any discussion of “vaccination reluctance” has to include when bad things happen because of the vaccine. Some response is expected – skin soreness and low-grade fever for a day or two. Those things happen because the person’s immune system is responding to the antigens. Then there are the “Medium Bad” responses, which include the child having a seizure. These are rare, and usually a one-time event with no long-term consequences. But what about the serious “adverse events”? On the one hand, they are very rare. On the other hand, they can be devastating.

But let’s compare risks. Measles vaccine can cause a brain swelling called “encephalitis”. It happens once in a million vaccinations. But so can natural measles. The risk is much higher with natural measles – one in a thousand infections. Two weeks I heard a woman doctor speak who had led a medical group to Africa. She showed a video of a child, probably six years old, who had contracted measles a year earlier, developed encephalitis, and who now couldn’t feed herself, speak, or walk. It is a tragedy.

Staying informed is helpful. The American Academy of Pediatrics (www.aap.org/immunization) and the Centers for Disease Control and Prevention (www.cdc.gov/vaccines) are good sites to explore. Let’s keep the discussion going.

 

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Mon, 07 Nov 2011 07:23:00 -0800 The Best Way to Prevent Illness http://www.amygivler.com/the-best-way-to-prevent-illness http://www.amygivler.com/the-best-way-to-prevent-illness

Screen_shot_2011-11-07_at_9
The photo that goes with today’s blog is probably from 1952, the last U.S. polio epidemic, when 57,000 people contracted the disease, which weakens nerves, usually temporarily. Yes, there are people in those tubes, called iron lungs. I can think of few places I’d rather avoid than the inside of an iron lung. Yet those people were probably grateful for them, since it allowed their lungs to move air in and out. Breathing is a wonderful thing.

In 1955 the Salk polio vaccine became available, and millions were vaccinated. The number of cases plummeted. Today America is considered free of polio, but there are pockets of polio in the world. In India, Nigeria, Pakistan, and Afghanistan it’s never been fully eradicated, and in Eastern Europe, Angola, Chad, Congo and Sudan it has re-emerged after once being conquered. So there’s nothing to keep it from coming back to the States if we all stopped being immunized.

Vaccines are the best thing we do in medicine. I’m all for preventing a disease rather than treating it – presuming, of course, that it’s treatable.

I went to a college preview day with my son on Saturday, and the admissions counselor was a peppy, funny guy. His list of things that an applicant to the school must do included sending in their vaccination record. “So be sure we get that record. We want to know that you are protected from rubella.” But he pronounced it with several seconds on the “Ru-” and then blasted out “Bella” with a silly little shake of his head. Everyone laughed, including me. “Whatever Ru-Bella is,” he said, and everyone laughed again.

And then I thought, “I am so glad that rubella is funny to him, and to, almost certainly, everyone in the room. I’m glad that he didn’t grow up with a sister who was deaf, blind, or mentally retarded from catching the disease in the womb from his mother.”

The fact that saying “rubella” can be funny is part of the success story of vaccines.

But several generations have now grown up without seeing the diseases that vaccines protect against. It’s easy to forget why getting immunized is important. That goes for doctors, also. I read about a survey of young doctors that showed an increasingly apathetic attitude toward vaccines. They just hadn’t seen the diseases.

I haven’t seen most of them, either, but I, at least, was trained in the 1980s by older doctors who remembered the diseases very well, and were therefore passionate about vaccines. I caught a bit of their passion. 

And now, I hope, I can pass on a bit of that passion to you.

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Wed, 02 Nov 2011 18:29:00 -0700 More Coffee, Less Depression http://www.amygivler.com/more-coffee-less-depression http://www.amygivler.com/more-coffee-less-depression

Screen_shot_2011-10-31_at_2
As if I need another excuse to drink coffee, here comes a study in the September issue of Archives of Internal Medicine which suggests that coffee drinking women get depressed less often. First a disclaimer: I love coffee, and would have a hard time giving it up if it suddenly turned out to be dangerous. But over the years I’ve seen study after study come out, and coffee drinking always seems to end up being beneficial.

This most recent study looked at a huge database – the Nurses’ Health Study – which has been following the health of female nurses since 1976. The researchers looked at 50,000 women who were not depressed at baseline. Then they looked at how much coffee they reported drinking, and whether they reported being diagnosed with depression over the next ten years. The more coffee women drank, the less likely they would be diagnosed with depression. In fact, the risk of depression in women who drank four or more cups a day was 20 percent lower than in the women who drank one cup of coffee, or less, a week.

For women who drank decaf, there was no impact on the rate of depression. Nor did getting caffeine from other sources (tea, chocolate) make depression less likely, but those sources have a lot less caffeine than coffee.

So for those of you who love your coffee, I’m not going to talk you out of it. In fact, I will meet you at Starbucks to discuss our mutual addiction.

By the way, if you are a female nurse between the ages of 22 and 46, the Nurses’ Health Study is recruiting a new batch of nurses. 230,000 nurses have been part of this huge study so far, and I understand that participating simply involves answering an online questionnaire once or twice a year. Check out http://www.nhs3.org if that interests you.

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Fri, 28 Oct 2011 06:10:00 -0700 What's the Substitute for Sugar? http://www.amygivler.com/whats-the-substitute-for-sugar http://www.amygivler.com/whats-the-substitute-for-sugar

Screen_shot_2011-10-28_at_7
So you have decided to lessen the amount of sugar you consume. Great! Now, what are the alternatives?

First, there are options that aren’t really alternatives at all. They are just sugar in another form. I’m talking about honey, maple sugar, date sugar, molasses, and agave nectar. They have the same amount of calories as sucrose, can rot your teeth to exactly the same extent, and raise your blood glucose just as rapidly. I’m not saying not to consume them – I love honey and maple syrup! – but being “natural” doesn’t make them more healthy.

Second, there are the “sugar alcohols”. Despite their name, they are not “alcoholic”! These have funny-sounding names, usually ending in “-tol”. So sorbitol, mannitol, xylitol, maltitol, erythritol and lactitol are in this group, as well as isomalt. Stevia (on the shelf as Pure Via or Truvia) is not technically a sugar alcohol, but it is lumped in with them because it has similar characteristics. Our bodies don’t completely absorb them so if we go overboard and consume a massive amount, they can cause bloating and diarrhea. And what are the advantages of these compounds? They are generally as sweet as sugar, but with only half the calories. Many of them occur in nature – in some fruit or vegetable – so a manufacturer using one can say, according to the FDA, that its food is “natural”. I think that is a stretch, but it is what is allowed.

Third – the artificial sweeteners. These are intensely sweet and are considered by the FDA to be “food additives” (not actual food) because they are essentially calorie-free. 

·      Acesulfame (Sunett, Sweet One) – 200 times sweeter than sugar

·      Aspartame (Equal, NutraSweet) – 220 times sweeter than sugar

·      Neotame (10,000 times sweeter than sugar)

·      Saccharin (SugarTwin, Sweet’N Low) – 400 times sweeter than sugar

·      Sucralose (Splenda) – 600 times sweeter than sugar

Often these leave a slightly bitter aftertaste, but some people don’t notice it. The advantage of using one of these is that you are avoiding a whole bunch of calories. A teaspoon of sugar has 16 calories, and one 12-ounce can of Coke has 8 teaspoons of sugar – 130 calories. Americans are drowning in sugar. A National Cancer Institute survey completed in 2004 showed that the average American eats more than 22 teaspoons of sugar a day (350 calories). Ugh. The average teen between ages 14 and 18 is eating a massive 34 teaspoons a day (549 calories). Double ugh.

So artificial sweeteners can step in and save us from all of those extra, empty calories, right? Not so fast. Though they are considered generally safe (they have been extensively studied) there are also people who react badly to them. Some people are allergic to one of them, and other people, though they may not be technically allergic, feel badly when they consume them.

My suggestion is in a new direction, altogether. What about training our taste buds to desire less sweetness? According to a 2009 Circulation article (http://circ.ahajournals.org/content/120/11/1011.full.pdf+html), our brains have pleasure centers, and sweet foods go straight to those  areas. Yes, you are hard-wired to enjoy sweetness. The trouble is that our brains, if they are getting an infusion of pleasurable sweetness, will suppress the normal feeling of “fullness”, and as a result we eat more than we need.

So how about choosing less often to eat sweet things, whether naturally or artificially sweetened? Then something sweet can be a treat.

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Mon, 24 Oct 2011 10:36:00 -0700 So How Much Meat Do You Really Need? http://www.amygivler.com/so-how-much-meat-do-you-really-need http://www.amygivler.com/so-how-much-meat-do-you-really-need

Screen_shot_2011-10-24_at_10
Continuing my celebration of real food (for Food Day – see post from October 19), today I’m asking, “How much protein do we really need?”

I’ve heard that a portion of meat is around 3 ounces, about the size of a deck of cards. That is very helpful. But surely we don’t all need exactly that. A highly active teenaged soccer player (my son) must have different protein needs than a mildly-active woman in her 50’s (me). Or so I thought.

First I did a little research. Actually, finding exact amounts was hard to pin down. Finally I came to two very helpful links. The first is put out by the USDA and is technically for health professionals looking for the exact nutritional needs of their patients. But it’s easy to use, and gives a wealth of information. 

Click on http://fnic.nal.usda.gov/interactiveDRI and put in your height and weight and age, then click on the nutrients you are wondering about how much you need, then “submit”. According to this, my son needs 70 grams of protein a day (which at 30 grams per ounce, is a bit more than 2 ounces), and I am right behind him at 69 ounces. Now remember, this is about the body’s needs. We’re talking survival.

Overshooting our needs by a little bit is a good idea, just to be safe. But that brings us back to the 3 ounce portion – the size of a deck of cards. And that’s once a day. 

And what about vegetarians, who don’t eat meat? Meat is not the only source of protein. If they are vegans (who avoid all animal products, including milk and eggs) then they can get their protein from beans, peas, and nuts, and soy products. Otherwise, eggs (up to four a week, to keep cholesterol down), cheese and dairy products can be eaten.

The second link I promised you is a helpful chart of all the different forms of protein – both how much is one ounce, and how much is three ounces (a serving size). http://www.choosemyplate.gov/foodgroups/proteinfoods_counts_table.html .

Finally, remember that red meat has a certain amount of fat buried in it. So limit this by choosing pieces with no obvious fat, and trim any fat from the edges before you cook it. Also, the skin of chicken hides a layer of fat underneath it. It’s better to eat poultry without the skin. I know I’m being a party-pooper for all of you who love that chicken skin. But going skinless is a simple way of reducing fat. Give it a try.

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Fri, 21 Oct 2011 08:02:00 -0700 It's Not The Real Thing http://www.amygivler.com/its-not-the-real-thing http://www.amygivler.com/its-not-the-real-thing

Screen_shot_2011-10-21_at_2
A discussion of real food leads naturally to the question: What is fake food? The fakest food I can think of is a sugary drink. Yes, I’m talking about Coke.

I know I’m on hallowed ground, for some, when I talk about Coke – especially here in the South where babies sometimes get it in their bottles (yes, I have seen this). I know people whose breakfast consists of several Cokes. 

But the South is also full of overweight people, many with diabetes and heart disease. And there is a connection between drinking sugar-saturated drinks and obesity.

A landmark study published in American Journal of Clinical Nutrition looked at 30 other studies (what in medicine is called a “meta-analysis”) which showed a clear connection between the amount of sugar-sweetened drinks imbibed and weight gain – in both children and adults. Since that 2006 study, 87 more articles and studies have referred to it, and supported its conclusions.

But what’s so bad about sugary soda? We have to drink something, don’t we? The problem is we were designed to drink water, and when we drink calories our bodies don't register it as food. True, consuming sugar does provide energy for the body. But our brains don’t perceive that we have consumed any calories when we drink something. So it marches along and gives us hunger pangs – even though we may have just drunk 500 calories of Coke. So our next meal is just as big as if we hadn’t just drunk all of those calories. The result? Weight gain. 

Also, that huge rush of sugar is rapidly absorbed into our bloodstream and often overwhelms our ability to deal with it. According to a 2010 Circulation article (http://circ.ahajournals.org/content/121/11/1356.full), repeatedly spiking our blood sugar like that is the path to diabetes. Also, that sugar spike increases the inflammatory markers in our bloodstream, which is the basis of heart disease.

Makes you want to get yourself a tall glass of water? Good. I’ll join you.

 

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Wed, 19 Oct 2011 07:50:00 -0700 Eating Real Food http://www.amygivler.com/eating-real-food http://www.amygivler.com/eating-real-food

Screen_shot_2011-10-19_at_11
In honor of Food Day, I’m going to post a few blogs about food. What is Food Day, you ask? It is a celebration of real food. The Center for Science in the Public Interest, the publisher of Nutrition Action Healthletter, a magazine I read regularly, has determined that October 24 is the day we should all make merry in honor of food. Real food.

All food is not alike. The convenience foods that so many of us Americans eat are heavily processed – containing refined grains rather than whole grains, sugar, lots of salt, and a high percentage of fat. The idea behind Food Day is to get us back to eating fruits and vegetables that start out in our kitchens in unprocessed form. Yes, this will mean taking time to slice and dice, and actually cooking.

The trouble with “processing” is that nutrients get removed in the process. When grains are refined, for instance, they have lost vitamins and minerals and fiber. They also become much more easily absorbed by our bodies. On the surface, it may seem desirable to eat easily-absorbed foods, but, actually, doing so leads to a spike in our blood glucose level. That spike is very hard on our bodies – and increases our risk of diabetes, heart disease, and gaining weight.

Our bodies are designed to slowly break down food and give our organs a steady supply of glucose. Food in its more natural state – whole grains, intact fruits and vegetables, nuts, less-fatty meats – does just that. Processing food does a lot of the work that our bodies were designed to do. By cutting corners, we put a stress on our bodies. That stress is unnecessary, and it’s unhealthy.

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler
Thu, 13 Oct 2011 13:36:00 -0700 The Thinning of America http://www.amygivler.com/the-thinning-of-america http://www.amygivler.com/the-thinning-of-america

Screen_shot_2011-10-13_at_5
Here’s a heartening statistic: Americans are getting lighter. Well, okay, I must be specific: Americans are getting slightly less fat.

Lest you think polls are only done for political purposes, Gallup has been doing a “Wellbeing Index” since 2008, consisting of phone interviews on health topics. Gallup’s latest poll, representing over 90,000 phone interviews in three months, shows that there is a slight decrease in the percentage of obese and overweight Americans, and a slight increase in “normal weight” folks.

The words “obese” and “overweight” are medical terms, determined solely from height and current weight. Having a Body Mass Index (BMI) over 30 means you are obese, and 25 to 29.9 means you are overweight. Normal weight is a BMI between 18.5 and 24.9. If you’ve never learned your BMI, calculate it here:  http://www.nhlbisupport.com/bmi . It’s a useful number to know.

The Gallup poll numbers won’t blow you out of the water – the percentage of obese Americans dropped from 26.2 to 25.8 percent compared with the three months earlier, and the overweight dropped from 36.1 to 35.8. The full results are here: http://www.gallup.com/poll/149975/Americans-Normal-Weight-Overweight.aspx

It may not seem like much, but I’m encouraged. Every little bit of trending toward normal weight means Americans are less susceptible to the myriad of medical problems that plague the overweight.

And people who are normal weight live longer. Information from the Framingham Heart Study, which has followed a large Massachusetts community since 1948, shows that being overweight at age 40 (all other things being equal) meant you had a lower life expectancy by three years. And being obese at age 40 meant your life expectancy was lower by seven years (women) or six years (men).

So let’s cinch our belts a little tighter and drop a few pounds. Then, when the Gallup people call we, too, can be part of this healthy trend.

Permalink | Leave a comment  »

]]>
http://files.posterous.com/user_profile_pics/1283057/IMG_0703.jpg http://posterous.com/users/hcGbEx84gcrNw Amy Givler MakingSenseOfMedicine Amy Givler